abstract：:The mitochondrial 18 kDa Translocator Protein (TSPO) was first detected by its capability to bind benzodiazepines in peripheral tissues and later also in glial cells in the brain, hence its previous most common name peripheral benzodiazepine receptor (PBR). TSPO has been implicated in various functions, including apop...

journal_title：Current molecular medicine

authors： Veenman L,Gavish M

更新日期：2012-05-01 00:00:00

abstract：:The generation of functional neural progenitor cells (NPCs) independent of donor brain tissue and embryonic tissues is of great therapeutic interest with regard to regenerative medicine and the possible treatment of neurodegenerative disorders. Traditionally, NPCs are derived through the differentiation of embryonic s...

journal_title：Current molecular medicine

authors： Tian C,Ambroz RJ,Sun L,Wang Y,Ma K,Chen Q,Zhu B,Zheng JC

更新日期：2012-02-01 00:00:00

abstract：:Maintenance of ex vivo hematopoietic stem cells (HSC) pool and its differentiated progeny is regulated by complex network of transcriptional factors, cell cycle proteins, extracellular matrix, and their microenvironment through an orchestrated fashion. Strides have been made to understand the mechanisms regulating in ...

journal_title：Current molecular medicine

authors： Aggarwal R,Lu J,Pompili VJ,Das H

更新日期：2012-01-01 00:00:00

abstract：:Structural multitude of nucleic acids serves basis for its multiple merits and applications. During structural transitions, significant to perform respective cellular functions, these DNA forms can vary from the single stranded to multi-stranded species. Hence, beyond the image of a monotonous DNA double-helix, there ...

journal_title：Current molecular medicine

authors： Kaushik M,Kaushik S,Bansal A,Saxena S,Kukreti S

更新日期：2011-12-01 00:00:00

abstract：:The identification of a relevant effector of Ran GTPase (Ran) signaling and its pathways could provide a novel approach to cancer therapeutics. With recent research highlighting the significant relationship between Ran expression and the occurrence and progression of cancer, the development of a small molecule compoun...

journal_title：Current molecular medicine

authors： Doherty KJ,McKay C,Chan KK,El-Tanani MK

更新日期：2011-11-01 00:00:00

abstract：:Abnormal and prolonged inflammatory reaction is seen in a wide variety of disorders, and high level of Tumor Necrosis Factor alpha (TNF-α) has been linked to these disorders. Therefore, modulation of TNF-α expression is important in the regulation of inflammatory disorders. In our previous study, we have shown that a ...

journal_title：Current molecular medicine

authors： Tang X,O'Reilly A,Asano M,Merrill JC,Yokoyama KK,Amar S

更新日期：2011-08-01 00:00:00

abstract：:Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine. This review focuses on the efficacies and molecular mechanisms of BG-induced anti-diabetic, anti-HIV, and antitumor activities contributed by over twenty ...

journal_title：Current molecular medicine

authors： Fang EF,Ng TB

更新日期：2011-07-01 00:00:00

abstract：:WHIM syndrome is a dominantly inherited primary immunodeficiency disorder representing the first identified example of human disease caused by mutations in the gene encoding for the chemokine receptor CXCR4. Pathogenesis is mediated by CXCR4 hyperfunction, leading to increased responsiveness to its unique ligand CXCL1...

journal_title：Current molecular medicine

authors： Dotta L,Tassone L,Badolato R

更新日期：2011-06-01 00:00:00

abstract：:Classical Hodgkin lymphoma (cHL) is now recognized as a B-cell-derived lymphoma which is characterized by only about 1% malignant pathognomonic Hodgkin and Reed-Sternberg (HRS) cells and an abundant infiltrate of reactive bystander cells. HRS cells are unique with respect to their lost B-cell-specific gene expression ...

journal_title：Current molecular medicine

authors： Schwarzer R,Jundt F

更新日期：2011-04-01 00:00:00

abstract：:Glutathione transferase Pi (GST-pi, GSTP) is known to strongly affect human susceptibility to several cancers, asthma and neurodegenerative disorders. As with other glutathione transferases, it catalyses the addition of reduced glutathione to electrophilic species, and it is important in metabolite detoxification. It ...

journal_title：Current molecular medicine

authors： Vasieva O

更新日期：2011-03-01 00:00:00

abstract：:Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the function of non-T cells, such as ant...

journal_title：Current molecular medicine

authors： Caruso R,Stolfi C,De Nitto D,Pallone F,Monteleone G

更新日期：2011-02-01 00:00:00

abstract：:The ocular lens is a non-vascular and non-innervated transparent organ that plays an important role in vision processing. This unique organ is derived from the embryonic ectoderm of the brain region through a complicated differentiation process in which apoptosis plays a key role. First, when the committed ectoderm be...

journal_title：Current molecular medicine

authors： Zhang L,Yan Q,Liu JP,Zou LJ,Liu J,Sun S,Deng M,Gong L,Ji WK,Li DW

更新日期：2010-12-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, ...

journal_title：Current molecular medicine

authors： Chakraborty C,Shah KD,Cao WG,Hsu CH,Wen ZH,Lin CS

更新日期：2010-11-01 00:00:00

abstract：:In recent years, the clinical validation of molecular targeted therapies inhibiting the action of pathogenic tyrosine kinase (TK) has been one of the most exciting developments in cancer research. In this context, medullary thyroid carcinoma (MTC) represents a promising model. It is well known that in MTC, the RET rec...

journal_title：Current molecular medicine

authors： Torino F,Paragliola RM,Barnabei A,Corsello SM

更新日期：2010-10-01 00:00:00

abstract：:Enteroviruses are common human pathogens involved in a wide spectrum of clinical outcomes ranging from mild or non-symptomatic illness to severe diseases with neurological and/or cardiac manifestation. Despite being responsible for significant morbidity and mortality especially in immunocompromised patients and infant...

journal_title：Current molecular medicine

authors： Schönhofer-Merl S,Wessely R

更新日期：2010-08-01 00:00:00

abstract：:Mistletoe is often used as complementary therapy in oncology. The anti-tumor effects of mistletoe (Iscador) are well documented in-vitro in respect to inhibition of cell proliferation, induction of apoptosis, segmental activation of immune competent cells and trapping of chemotherapeutic drugs within cancer cells by m...

journal_title：Current molecular medicine

authors： Matthes H,Friedel WE,Bock PR,Zänker KS

更新日期：2010-06-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is reported to play a protective role against diabetic vascular complications through its anti-oxidative properties. However, since a commercially available kit is not suitable for measurement of serum PEDF in humans, kinetics and regulation of serum PEDF are not known in these...

journal_title：Current molecular medicine

authors： Fukami K,Yamagishi SI,Okuda S

更新日期：2010-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Although simple or bland steatosis follows a relatively benign clinical course, NASH can potentially progress to cirrhosis (approximately 10 to 15 percent) and ...

journal_title：Current molecular medicine

authors： Estep JM,Birerdinc A,Younossi Z

更新日期：2010-03-01 00:00:00

abstract：:Osteopontin (OPN) is a matricellular protein that is produced by multiple tissues in our body and is most abundant in bone. It is also produced by cancer cells and plays a determinative role in the growth, progression and metastasis of cancer. Clinically, OPN has been reported to be upregulated in tumor cells per se; ...

journal_title：Current molecular medicine

authors： Shevde LA,Das S,Clark DW,Samant RS

更新日期：2010-02-01 00:00:00

abstract：:Primary malignancies of the liver and the gastrointestinal tract constitute one of the main health problems worldwide. Together, these types of tumour are the first cause of death due to cancer, followed by lung and breast cancer respectively. One important limitation in the treatment of these tumours is that, with a ...

journal_title：Current molecular medicine

authors： Marin JJ,Romero MR,Martinez-Becerra P,Herraez E,Briz O

更新日期：2009-12-01 00:00:00

abstract：:The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retina...

journal_title：Current molecular medicine

authors： Tolentino MJ

更新日期：2009-11-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have become increasingly widely used to determine regions of the genome which may contain loci influencing the risk of neurological disorders. While linkage studies have identified genes that cause a number of Mendelian disorders, linkage analysis is less well suited for the more...

journal_title：Current molecular medicine

authors： Gubitz AK,Gwinn K

更新日期：2009-09-01 00:00:00

abstract：:Despite advances in biomedical sciences, the prognosis of patients with brain tumors remains poor. Effective treatment is lacking for these central nervous system (CNS) cancers. Targeted immunotoxins are a new class of therapeutic approaches that have emerged for the treatment of human cancers. In this approach, tumor...

journal_title：Current molecular medicine

authors： Puri S,Puri S,Mahapatra AK,Hussain E,Sarkar C,Sinha S,Joshi BH

更新日期：2009-08-01 00:00:00

abstract：:Deregulation of the PI3K pathway is common in human cancer. The basic players in this pathway are the kinases PI3K and AKT and the phosphatase PTEN. This review will summarize some of the key animal models that have helped us understand this signaling network and its contribution to tumorigenesis. Recently, great adva...

journal_title：Current molecular medicine

authors： Renner O,Carnero A

更新日期：2009-06-01 00:00:00

abstract：:Hypoxia or oxygen deficiency is a salient feature of solid tumors. Hypoxic tumors are often resistant to conventional cancer therapies, and tumor hypoxia correlates with advanced stages of malignancy. Hypoxic tumors appear to be poorly differentiated. Increasing evidence suggests that hypoxia has the potential to inhi...

journal_title：Current molecular medicine

authors： Kim Y,Lin Q,Glazer PM,Yun Z

更新日期：2009-05-01 00:00:00

abstract：:Type 2 Diabetes occurs as a result of defects in insulin secretion and its function. Although mechanisms of disease are not fully elucidated, it is recognized that a progressive decline in insulin secretory capacity is responsible for its occurrence and natural course. Metabolic syndrome, known to be a precursor of Ty...

journal_title：Current molecular medicine

authors： Tavintharan S,Chi LS,Fang SC,Arunmozhiarasi A,Jeyaseelan K

更新日期：2009-04-01 00:00:00

abstract：:p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this revi...

journal_title：Current molecular medicine

authors： Pellegrini M,Baldari CT

更新日期：2009-04-01 00:00:00

abstract：:Central Nervous System (CNS) tuberculosis is a serious, often fatal form of tuberculosis, predominantly affecting young children. HIV co-infection and drug resistant strains of Mycobacterium tuberculosis are making the diagnosis and treatment of CNS tuberculosis more complicated. Current concepts about the pathogenesi...

journal_title：Current molecular medicine

authors： Be NA,Kim KS,Bishai WR,Jain SK

更新日期：2009-03-01 00:00:00

abstract：:Strong epidemiological evidence indicates that migraine, especially migraine with aura, is associated with increased risk of ischemic stroke. However, the precise mechanisms of such a relation are currently not fully elucidated and are still a matter of speculation. Migraine may directly cause an ischemic event (i.e, ...

journal_title：Current molecular medicine

authors： Pezzini A,Del Zotto E,Giossi A,Volonghi I,Grassi M,Padovani A

更新日期：2009-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an organ-specific autoimmune disease resulting from the specific destruction of insulin-producing pancreatic beta-cells, culminating in a state of hypoinsulinemia and hyperglycemia. Pathogenesis of T1D comprises complex series of events from the initial sensitization of antigen-presenting cell...

journal_title：Current molecular medicine

authors： Kim HS,Lee MS

更新日期：2009-02-01 00:00:00

abstract：:Non-invasive energy metabolism measurements in brain tumors in vivo are now performed widely as molecular imaging by positron emission tomography. This capability has developed from a large number of basic and clinical science investigations that have cross fertilized one another. Apart from precise anatomical localiz...

journal_title：Current molecular medicine

authors： Schaller BJ,Cornelius JF,Sandu N,Buchfelder M

更新日期：2008-12-01 00:00:00

abstract：:p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is ma...

journal_title：Current molecular medicine

authors： Zhang J,Chen X

更新日期：2008-12-01 00:00:00

abstract：:Sickle cell disease (SCD) and beta-thalassemia (also referred to as beta-thalassemia) are common hereditary hemoglobinopathies with differing pathophysiologies and clinical courses. However, patients with both diseases exhibit increased platelet and coagulation activation, as well as decreased levels of natural antico...

journal_title：Current molecular medicine

authors： Singer ST,Ataga KI

更新日期：2008-11-01 00:00:00

abstract：:Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism ...

journal_title：Current molecular medicine

authors： Aso Y

更新日期：2008-09-01 00:00:00

abstract：:Eicosanoids are diverse mediators of inflammation that derive from a single cell membrane phospholipid-associated precursor, arachidonic acid. This precursor is metabolized to several groups of lipid mediators, including (but not limited to) prostaglandins, leukotrienes, and lipoxins, in a tightly regulated, coordinat...

journal_title：Current molecular medicine

authors： Boyce JA

更新日期：2008-08-01 00:00:00

abstract：:Asthma, chronic obstructive pulmonary disorder (COPD), and cystic fibrosis (CF), chronic diseases of the airways, are characterized by symptoms such as inflammation of the lung tissue, mucus hypersecretion, constriction of the airways, and excessive fibrosis of airway tissue. Transforming growth factor (TGF)-beta, a c...

journal_title：Current molecular medicine

authors： Moore B,Murphy RF,Agrawal DK

更新日期：2008-08-01 00:00:00

abstract：:Necrotic cell death has long been considered an accidental and uncontrolled mode of cell death. But recently it has become clear that necrosis is a molecularly regulated event that is associated with pathologies such as ischemia-reperfusion (IR) injury, neurodegeneration and pathogen infection. The serine/threonine ki...

journal_title：Current molecular medicine

authors： Vanlangenakker N,Vanden Berghe T,Krysko DV,Festjens N,Vandenabeele P

更新日期：2008-05-01 00:00:00

abstract：:Autophagy is a bulk cytosolic degradative process which in the last few years has become a key pathway for the advancement of molecular medicine. Autophagy (cellular self-eating) has several implications in human disorders involving accumulation of cytosolic protein aggregates such as Alzheimer, Parkinson, Huntington ...

journal_title：Current molecular medicine

authors： Lerena C,Calligaris SD,Colombo MI

更新日期：2008-03-01 00:00:00

abstract：:Conformational or misfolding diseases are a large class of devastating human disorders associated with protein misfolding and aggregation. Most conformational diseases are caused by a combination of genetic and environmental factors, suggesting that spontaneous events can destabilize the protein involved in the pathol...

journal_title：Current molecular medicine

authors： Cardinale A,Biocca S

更新日期：2008-02-01 00:00:00

abstract：:HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1-ind...

journal_title：Current molecular medicine

authors： Rauvala H,Rouhiainen A

更新日期：2007-12-01 00:00:00